The research behind every gummy we make.
Every Amp Up formula starts with peer-reviewed human clinical trials on the individual active ingredients. Pick a product below and explore the science behind why it's in our jar.
For Eyes & Screen Life
Pure Vision
A daily gummy built around the exact lutein + zeaxanthin doses used in recent double-blind clinical trials on screen fatigue and macular health — paired with bilberry extract for ciliary muscle recovery.
What's inside each serving
Lutein
Macular carotenoid; filters high-energy blue light reaching the retina.
Zeaxanthin
Concentrates in the fovea; works synergistically with lutein.
Bilberry Extract
Anthocyanin-rich; studied for ciliary muscle recovery after screen work.
Vitamin A
Essential for rhodopsin synthesis and low-light vision.
How it works
Deposit at the macula
Lutein and zeaxanthin are absorbed and selectively deposited in the macular pigment, where they filter blue light and neutralize free radicals.
Stabilize the tear film
Carotenoids support lipid-layer stability, which is tied to reduced dryness and reduced break-up time during long screen sessions.
Support ciliary recovery
Bilberry anthocyanins support microcirculation and ciliary muscle accommodation after prolonged near-focus work.
What we mean by "clinical research"
We prioritize studies that meet these four criteria.
A study is only as reliable as its design. When we cite research, we look for trials that meet the same standards used by leading peer-reviewed journals:
- Human clinical trials — conducted with real people, not just lab models.
- Randomized and placebo-controlled — participants randomly assigned; outcomes compared against placebo.
- Double-blind — neither participants nor researchers know who's getting the active ingredient.
- Peer-reviewed publication — findings reviewed by independent experts in the field.
The essential takeaways
- The lutein (10 mg) and zeaxanthin (2 mg) doses match those used in a 2025 double-blind RCT on screen-related eye comfort.
- Four randomized, placebo-controlled trials directly support the active ingredients in this formula.
- Bilberry extract (100 mg) has been studied in trials with up to 281 office workers, showing measurable improvements in eye fatigue under screen workloads.
- All referenced studies examine individual active ingredients, not Amp Up branded products.
The research
Lutein + zeaxanthin — visual comfort during prolonged screen use
Lopresti & Smith recruited 70 adults using screens 6+ hours daily and randomized them to 10 mg lutein + 2 mg zeaxanthin or placebo for six months. The ingredient doses match exactly what is in every serving of Pure Vision.
- Significantly improved tear film stability vs. placebo, measured by Schirmer tear test and tear film break-up time.1
- Accelerated photo-stress recovery time, indicating reduced glare sensitivity and more resilient retinal photoreceptors.1
- Zero adverse effects reported across all 70 participants over the full 180-day period.1
Tear film stability — Lopresti & Smith, 2025
Schirmer tear test & break-up time
Lutein + zeaxanthin — macular pigment density and eye strain
Parekh et al. conducted a placebo-controlled gummy trial in 60 participants over 180 days, measuring macular pigment optical density (MPOD) — a validated biomarker for how effectively the macula filters blue light.
- Increased MPOD by 25% vs. a +3% non-significant change in the placebo group.2
- Significantly reduced eye strain and fatigue, measured by validated questionnaires covering visual discomfort and difficulty focusing.2
- Improved visual processing speed, suggesting macular carotenoids support both comfort and visual performance.2
Bilberry extract — ciliary muscle recovery after screen work
Kosehira et al. recruited 109 adults with ocular fatigue and randomized them to 240 mg bilberry extract or placebo for 12 weeks. Ciliary muscle function was measured before and after standardized VDT tasks.
- Significantly improved ciliary muscle accommodation after VDT tasks at weeks 8 and 12.3
- Produced a progressive, cumulative effect, reaching statistical significance by week 8 and strengthening by week 12.3
Bilberry extract — screen eye fatigue in office workers
Ozawa et al. ran one of the largest RCTs on screen-related ocular fatigue: 281 office workers aged 20–40 randomized to bilberry extract or placebo for 8 weeks.
- Improved critical flicker fusion (CFF), a validated measure of retinal fatigue and visual processing speed, significantly vs. placebo.4
- Improved near-point accommodation and preserved the eye's focusing ability during prolonged screen work.4
- Improved tear film quality and reduced subjective symptoms including dryness, heaviness, and blurred vision.4
Vitamin A — rhodopsin and low-light vision
Vitamin A is a required substrate for the synthesis of rhodopsin, the photopigment rod cells use to detect low light. Adequate vitamin A supports normal dark adaptation and low-light vision.
- Essential for the visual cycle — retinal (the aldehyde form of vitamin A) combines with opsin to form rhodopsin in photoreceptor outer segments.5
- Recognized by the NIH and WHO as critical for normal vision throughout life.5
1 6-month RCT, n=70. Lopresti AL & Smith SJ, Frontiers in Nutrition, 2025. PMID: 39963662.
2 180-day RCT, n=60. Parekh R & Hammond BR Jr, Advances in Therapy, 2024. PMID: 38363462.
3 12-week RCT, n=109. Kosehira M et al., Nutrients, 2020. PMC: PMC7146147.
4 8-week RCT, n=281. Ozawa Y et al., J Nutr Health Aging, 2015. PMID: 25923485.
5 NIH Office of Dietary Supplements, Vitamin A & Carotenoids — Health Professional Fact Sheet.
* These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
** All referenced studies examine individual active ingredients, not Amp Up branded products.
For Nightly Rest
Snooze Mode
A sugar-free nighttime gummy built around melatonin, magnesium, and L-theanine — three of the most-studied non-habit-forming ingredients for falling asleep faster and sleeping more soundly.
What's inside each serving
Melatonin
The body's natural sleep-signaling hormone — the most studied sleep-onset ingredient.
Magnesium
Supports GABA activity and relaxation; helps the nervous system wind down.
L-Theanine
Amino acid from green tea; promotes calm without sedation.
Vitamin B6
Cofactor in serotonin → melatonin conversion.
How it works
Signal bedtime
Oral melatonin binds to MT1 and MT2 receptors, reinforcing the body's natural "it's nighttime" signal and shortening time to sleep onset.
Calm the system
Magnesium supports GABA-A receptor activity and parasympathetic tone, reducing physical and mental restlessness before bed.
Quiet the mind
L-theanine supports alpha-wave EEG activity associated with relaxed wakefulness — the state that leads to easier sleep onset.
The essential takeaways
- Melatonin is the most clinically studied sleep-onset ingredient — a meta-analysis of 19 RCTs confirms reduced time to fall asleep.
- Magnesium supports relaxation via GABA regulation and has been studied in RCTs on sleep quality, melatonin production, and cortisol reduction.
- L-theanine supports relaxation and improved sleep satisfaction without next-day grogginess, confirmed in a 4-week double-blind RCT.
- All referenced studies examine individual active ingredients, not Amp Up branded products.
The research
Melatonin — sleep onset latency and sleep quality
Ferracioli-Oda et al. analyzed 19 placebo-controlled trials totaling 1,683 participants. Meta-analyses represent the highest level of clinical evidence available.
- Significantly reduced sleep onset latency vs. placebo across all 19 included trials.1
- Significantly increased total sleep time on average compared to placebo nights.1
- Significantly improved overall sleep quality with no evidence of tolerance or dependence across included studies.1
Sleep onset latency — Ferracioli-Oda et al., 2013
Pooled effect across 19 RCTs (n=1,683)
Magnesium — sleep quality in adults
Abbasi et al. randomized 46 adults to magnesium or placebo for 8 weeks, measuring sleep quality via the Pittsburgh Sleep Quality Index (PSQI), serum melatonin, and cortisol.
- Significantly improved PSQI total score, a validated composite measure covering sleep latency, duration, and daytime dysfunction.2
- Increased serum melatonin concentration, suggesting magnesium supports endogenous sleep hormone production.2
- Reduced serum cortisol levels, a stress hormone that interferes with sleep onset.2
L-theanine — relaxation and sleep preparation
Hidese et al. randomized 30 healthy adults to 200 mg L-theanine or placebo for 4 weeks, measuring sleep quality and stress-related symptoms.
- Significantly improved sleep satisfaction and reduced sleep latency versus placebo.3
- Reduced stress and anxiety scores, supporting L-theanine's role as a relaxation-promoting compound without sedation.3
- Improved next-day alertness, suggesting sleep-quality improvements translated into measurable daytime cognitive benefits.3
Melatonin — shift-work and irregular sleep schedules
A Cochrane systematic review examining melatonin's effect on sleep timing in individuals with circadian rhythm disruption from shift work, travel, or irregular schedules.
- Extended daytime sleep duration following melatonin administration compared to placebo in shift workers.4
- Did not produce next-day impairment on alertness or work performance, supporting melatonin's favorable tolerability profile.4
Vitamin B6 — melatonin biosynthesis support
Vitamin B6 (as pyridoxal-5-phosphate) is a required cofactor for the enzymes that convert tryptophan → 5-HTP → serotonin → melatonin. Adequate B6 status supports the body's own production of the sleep-signaling hormone.
- Essential cofactor in aromatic-L-amino-acid decarboxylase, the enzyme producing serotonin (melatonin's precursor).5
1 Meta-analysis of 19 RCTs, n=1,683. Ferracioli-Oda E et al., PLOS ONE, 2013. PMID: 23691095.
2 8-week RCT, n=46. Abbasi B et al., J Res Med Sci, 2012. PMID: 23853635.
3 4-week RCT, n=30. Hidese S et al., Nutrients, 2019. PMID: 31623400.
4 Liira J et al., Cochrane Database of Systematic Reviews, 2014. PMID: 25113164.
5 NIH Office of Dietary Supplements, Vitamin B6 — Health Professional Fact Sheet.
* These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
** All referenced studies examine individual active ingredients, not Amp Up branded products.
For Weight Management
Slim Power
African mango extract, L-carnitine, and targeted B vitamins — ingredients clinically studied for appetite regulation, fatty acid transport, and the metabolic machinery that turns food into energy.
What's inside each serving
African Mango Extract
Irvingia gabonensis seed extract; studied for appetite and metabolic markers.
L-Carnitine Tartrate
Transports long-chain fatty acids into mitochondria for oxidation.
Choline
Essential nutrient involved in lipid metabolism and liver function.
Vitamin B12
Essential cofactor in cellular energy production.
How it works
Regulate appetite signals
Irvingia gabonensis has been studied for its effect on leptin and adiponectin — hormones that regulate hunger and fat storage.
Shuttle fat into cells
L-carnitine moves long-chain fatty acids across the inner mitochondrial membrane — the required step before fat can be burned for energy.
Power the metabolic machinery
B vitamins and choline serve as cofactors in the dozens of enzymatic steps that convert carbohydrates, fats, and protein into ATP.
The essential takeaways
- African mango extract has been studied in double-blind RCTs showing reductions in body weight and waist circumference alongside sensible diet habits.
- L-carnitine is supported by a meta-analysis of 9 RCTs (n=911) showing significant body weight reduction.
- Choline and B12 are essential cofactors in fat and energy metabolism — deficiency is directly associated with fatigue.
- All referenced studies examine individual active ingredients, not Amp Up branded products. Weight management results depend on overall diet and activity.
The research
African mango extract — body weight and metabolic markers
Ngondi et al. randomized 102 overweight volunteers to 150 mg Irvingia gabonensis seed extract twice daily or placebo for 10 weeks. No exercise protocol was mandated.
- Reduced body weight significantly vs. placebo over the 10-week period.1
- Reduced waist circumference, a clinically relevant measure of visceral adiposity and metabolic risk.1
- Improved fasting blood glucose and LDL cholesterol, consistent with adiponectin and leptin regulation mechanisms.1
Body weight reduction — Ngondi et al., 2009
n=102 overweight adults, no exercise protocol
L-carnitine — body weight and BMI
Pooyandjoo et al. conducted a systematic review and meta-analysis of 9 RCTs examining L-carnitine supplementation on body weight and composition across 911 participants.
- Significantly reduced body weight vs. placebo/control, consistent across diverse populations.2
- Reduced BMI significantly, supporting L-carnitine's role in fatty acid transport into mitochondria.2
Irvingia gabonensis — leptin and adiponectin regulation
Oben et al. examined Irvingia gabonensis' effects on adipokines — the hormones released by fat tissue that regulate appetite and metabolism.
- Significantly increased adiponectin, a hormone associated with improved insulin sensitivity.3
- Decreased leptin levels, consistent with reduced leptin resistance in overweight participants.3
L-carnitine — exercise fat oxidation
Wall et al. measured muscle carnitine content and energy metabolism during exercise after 24 weeks of L-carnitine supplementation paired with carbohydrate.
- Increased muscle total carnitine content, the first demonstration that oral supplementation can meaningfully raise muscle carnitine stores.4
- Reduced muscle glycogen utilization during low-intensity exercise, consistent with increased reliance on fat as fuel.4
Choline — fat metabolism and liver function
Choline is required for the synthesis of phosphatidylcholine, a key component of VLDL particles that transport fat out of the liver.
- Essential for lipid transport — choline is required for the VLDL particles that move fats through the body.5
1 10-week RCT, n=102. Ngondi JL et al., Lipids in Health and Disease, 2009. PMID: 19765478.
2 Meta-analysis of 9 RCTs, n=911. Pooyandjoo M et al., Obesity Reviews, 2016. PMID: 27335245.
3 10-week RCT, n=72. Oben JE et al., Lipids in Health and Disease, 2008. PMID: 18500999.
4 24-week RCT. Wall BT et al., J Physiol, 2011. PMID: 21224234.
5 NIH Office of Dietary Supplements, Choline — Health Professional Fact Sheet.
* These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
** All referenced studies examine individual active ingredients, not Amp Up branded products. Weight management depends on overall diet, exercise, and lifestyle.
For Daily Immune Support
Immune Guard
High-potency vitamin C and D3, zinc, and elderberry — built around the nutrients and botanicals with the deepest bench of immune-focused clinical research.
What's inside each serving
Vitamin C
The most extensively studied nutrient for immune-cell function and antioxidant defense.
Vitamin D3
Supports antimicrobial peptide expression; linked to respiratory tract health.
Zinc
Essential trace mineral for T-cell and neutrophil function.
Elderberry Extract
Sambucus nigra; rich in anthocyanins studied for seasonal respiratory support.
How it works
Strengthen the first line
Vitamin C supports the skin barrier and epithelial integrity of respiratory tissue; vitamin D supports antimicrobial peptide expression at mucosal surfaces.
Activate immune cells
Zinc is required for T-cell development and neutrophil function; vitamin C is concentrated in leukocytes.
Modulate seasonal challenges
Elderberry anthocyanins have been studied for their effects on inflammatory mediators during upper respiratory episodes.
The essential takeaways
- Vitamin C is the most extensively studied nutrient for immune function, with hundreds of RCTs on immune-cell activity.
- Vitamin D3 is supported by a 25-RCT meta-analysis (n=11,321) showing reduced risk of acute respiratory tract infection.
- Elderberry extract reduced flu duration by an average of 4 days in a double-blind RCT.
- All referenced studies examine individual active ingredients, not Amp Up branded products.
The research
Vitamin D3 — respiratory infection prevention
Martineau et al. conducted a landmark meta-analysis of 25 RCTs involving 11,321 participants, examining vitamin D3 supplementation and the risk of acute respiratory tract infections.
- Significantly reduced risk of acute respiratory infection vs. placebo across all 25 included trials.1
- Provided greatest benefit to deficient individuals — those with low baseline vitamin D showed the strongest protective effect.1
- Safe and well-tolerated across all 25 trials with no serious adverse effects.1
Respiratory infection risk reduction — Martineau et al., 2017
Pooled across 25 RCTs (n=11,321)
Elderberry extract — cold and flu duration and severity
Zakay-Rones et al. randomized 60 adults with influenza to elderberry syrup or placebo 4× daily for 5 days, tracking illness progression, symptom severity, and recovery time.
- Reduced flu duration by an average of 4 days — full recovery in 2–6 days vs. 6–10 days in the control group.2
- Significantly reduced symptom severity including fever, muscle aches, headache, and nasal congestion.2
- Reduced use of rescue medication — fewer elderberry participants required pain relievers or decongestants.2
Zinc — common cold duration
Hemilä & Chalker pooled placebo-controlled trials on zinc lozenges and acute cold duration.
- Shortened common-cold duration in the pooled analysis, with larger effects at higher daily doses.3
- Supports the role of zinc as a cofactor for hundreds of immune-related enzymes and transcription factors.3
Vitamin C — common cold prevention and duration
Hemilä & Chalker's Cochrane review is one of the most comprehensive analyses of vitamin C and the common cold ever conducted.
- Reduced the duration of colds by an average of 8% in adults and 14% in children across regular supplementation trials.4
- Reduced cold incidence in athletes and people exposed to extreme physical stress by approximately half.4
Vitamin D3 — influenza prevention in children
Urashima et al. randomized 334 schoolchildren to vitamin D3 or placebo for the winter season, tracking laboratory-confirmed influenza A.
- Significantly reduced influenza A incidence in the vitamin D group vs. placebo.5
1 Meta-analysis of 25 RCTs, n=11,321. Martineau AR et al., BMJ, 2017. PMID: 28202713.
2 RCT, n=60. Zakay-Rones Z et al., J Int Med Res, 2004. PMID: 15080016.
3 Meta-analysis. Hemilä H & Chalker E, JRSM Open, 2017. PMID: 28515951.
4 Cochrane review, 29 trials, n=11,306. Hemilä H & Chalker E, Cochrane DB Syst Rev, 2013. PMID: 23440782.
5 RCT, n=334. Urashima M et al., Am J Clin Nutr, 2010. PMID: 20219962.
* These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
** All referenced studies examine individual active ingredients, not Amp Up branded products.
For Clean Energy
Full Energy
A smooth, focused energy gummy built around the clinically-studied caffeine + L-theanine combination — plus taurine and B vitamins that power cellular energy metabolism.
What's inside each serving
Caffeine
About half a cup of coffee; paired with L-theanine for smoother alertness.
L-Theanine
Balances caffeine with relaxed focus and reduced jitters.
Taurine
Amino sulfonic acid involved in mitochondrial function.
Vitamin B12
Required for cellular energy production and red blood cell formation.
How it works
Block the brake
Caffeine blocks adenosine receptors — the "tired" signal — producing increased alertness and wakefulness.
Smooth the edges
L-theanine increases alpha-wave activity and dampens the jittery edge caffeine can produce, for cleaner focus.
Fuel the mitochondria
B vitamins and taurine support the enzymes in the Krebs cycle and electron transport chain — where cells actually generate ATP.
The essential takeaways
- The caffeine + L-theanine combination is one of the most replicated findings in nootropic research, consistently outperforming either ingredient alone on focus and attention.
- Taurine improves endurance performance and reduces oxidative stress across 10 reviewed clinical trials.
- B vitamins are essential cofactors in cellular energy production; deficiency is directly associated with fatigue.
- All referenced studies examine individual active ingredients, not Amp Up branded products.
The research
Caffeine + L-theanine — focus, attention, and alertness
Haskell et al. tested caffeine alone, L-theanine alone, the combination, and placebo in 27 young adults in a fully counterbalanced crossover design. This is considered the foundational paper on the caffeine–theanine combination.
- Significantly improved speed of attention switching vs. placebo and vs. either ingredient alone — demonstrating a synergistic interaction.1
- Improved alertness and reduced mental fatigue more effectively than caffeine alone, with L-theanine providing smoother, more sustained focus.1
- Reduced headache incidence compared to caffeine alone, consistent with L-theanine attenuating some of caffeine's side effects.1
Attention & alertness — Haskell et al., 2008
Crossover RCT, n=27, caffeine+theanine combination arm
Taurine — exercise performance and energy metabolism
Waldron et al. reviewed 10 clinical trials examining taurine supplementation on endurance performance, muscle function, and cognitive outcomes.
- Improved time-to-exhaustion and endurance performance across multiple exercise modalities, consistent with taurine's role in mitochondrial function.2
- Reduced exercise-induced oxidative stress markers, suggesting taurine's antioxidant properties protect muscle and nerve cells.2
Caffeine + L-theanine — cognitive performance under demanding tasks
Owen et al. examined performance on cognitively demanding tasks after dosing with caffeine, L-theanine, both, or placebo.
- Combination improved accuracy on attention-switching tasks more than either ingredient alone.3
- Reduced susceptibility to distraction during task performance.3
B vitamins — energy metabolism and fatigue
Tardy et al. reviewed the role of the eight B vitamins in metabolism and fatigue, summarizing the evidence that inadequate B vitamin status is causally linked to reduced cellular energy production and subjective tiredness.
- Each B vitamin acts as a coenzyme in the mitochondrial pathways that produce ATP from food.4
- Deficiency in B12 or folate specifically is associated with anemia, fatigue, and cognitive slowing.4
Caffeine — physical and mental performance
Grgic et al. compiled meta-analytic evidence on caffeine's effect on muscular strength, power, endurance, and cognitive performance.
- Moderate doses improved endurance and reduced perceived exertion consistently across studies.5
- Improved reaction time and vigilance, particularly in sleep-deprived or fatigued states.5
1 Crossover RCT, n=27. Haskell CF et al., Biological Psychology, 2008. PMID: 18006208.
2 Systematic review of 10 trials. Waldron M et al., J Int Soc Sports Nutr, 2021. PMID: 33468053.
3 Owen GN et al., Nutritional Neuroscience, 2008. PMID: 18681988.
4 Tardy AL et al., Nutrients, 2020. PMID: 31963141.
5 Grgic J et al., British Journal of Sports Medicine, 2020. PMID: 30926628.
* These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
** All referenced studies examine individual active ingredients, not Amp Up branded products.
For Skin From Within
Face Glow
A beauty-from-within gummy built on astaxanthin, grape seed OPCs, and coenzyme Q10 — three of the most clinically validated antioxidants for skin elasticity, wrinkle depth, and photoprotection.
What's inside each serving
Grape Seed Extract
95% OPCs; among the most studied polyphenols for photoprotection.
Astaxanthin
A marine carotenoid with exceptional antioxidant capacity.
Coenzyme Q10
Mitochondrial cofactor that declines with age; supports dermal fibroblast energy.
Biotin
B-vitamin involved in the structure of hair, skin, and nails.
How it works
Neutralize oxidative stress
Astaxanthin and grape seed OPCs quench reactive oxygen species generated by UV exposure and metabolism — the drivers of collagen breakdown.
Support dermal energy
CoQ10 is a required carrier in the mitochondrial electron transport chain; dermal fibroblasts use it to produce collagen and elastin.
Preserve the skin barrier
Reducing lipid peroxidation helps maintain tight junctions and water retention, which translates to smoother microrelief and better moisture.
The essential takeaways
- Grape seed extract (95% OPC) is among the most studied polyphenols for skin photoprotection and antioxidant defense against UV-induced collagen degradation.
- Astaxanthin — a 16-week double-blind RCT confirmed improvements in skin elasticity, wrinkle depth, and moisture using validated clinical instruments.
- Coenzyme Q10 significantly reduced wrinkle score and improved skin microrelief in a double-blind RCT.
- All referenced studies examine individual active ingredients, not Amp Up branded products.
The research
Astaxanthin — skin elasticity, wrinkles, and moisture
Tominaga et al. randomized 65 healthy women to astaxanthin or placebo for 16 weeks. Skin parameters were measured objectively using cutometry (elasticity), profilometry (wrinkle depth), and corneometry (moisture).
- Significantly improved skin elasticity measured by cutometry — an objective biomechanical measure of skin rebound.1
- Reduced wrinkle depth around the eye area, as measured by 3D skin profilometry.1
- Improved skin moisture content, consistent with astaxanthin protecting the skin barrier from oxidative degradation.1
Skin elasticity & wrinkle depth — Tominaga et al., 2018
Cutometry + profilometry, n=65 women (astaxanthin)
Grape seed extract — UV-induced pigmentation
Ni et al. randomized 30 patients with UV-induced hyperpigmentation (chloasma) to 100 mg grape seed extract 3× daily or placebo for 6 months.
- Significantly reduced hyperpigmentation — melanin index scores improved significantly vs. placebo.2
- Improved overall skin tone uniformity, supporting GSE's role in modulating melanin overproduction.2
Coenzyme Q10 — skin anti-aging
Žmitek et al. randomized 33 healthy women to 50 mg oral CoQ10 or placebo for 12 weeks, measuring skin microrelief, wrinkle score, and antioxidant capacity via quantitative skin imaging.
- Significantly reduced wrinkle score vs. placebo, consistent with CoQ10's role in dermal fibroblast mitochondrial function.3
- Improved skin microrelief and texture, with surface irregularities decreasing significantly in the CoQ10 group.3
Astaxanthin — UV-induced skin deterioration
Ito et al. examined astaxanthin's effect on UV-exposed skin over 10 weeks with controlled UV provocation.
- Reduced UV-induced moisture loss in the astaxanthin group vs. placebo.4
- Preserved texture and firmness at UV-exposed sites, consistent with systemic photoprotection.4
Grape seed OPCs — antioxidant activity
A review of the antioxidant and anti-inflammatory effects of oligomeric proanthocyanidins from grape seed, covering skin-relevant mechanisms.
- Demonstrated potent free-radical scavenging, often cited as several times more effective than vitamins C and E in vitro.5
- Inhibited collagen and elastin degradation enzymes (collagenase, elastase) in multiple studies.5
1 16-week RCT, n=65. Tominaga K et al., Nutrients, 2018. PMID: 29441586.
2 6-month RCT, n=30. Ni Z et al., Phytother Res, 2004. PMID: 15478206.
3 12-week RCT, n=33. Žmitek K et al., BioFactors, 2017. PMID: 28393912.
4 10-week RCT, n=23. Ito N et al., Nutrients, 2021. PMID: 32560125.
5 Bagchi D et al., J Med Food, 2003. PMID: 14585189.
* These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
** All referenced studies examine individual active ingredients, not Amp Up branded products.
For Growing Kids
Kids Bone Support
A sugar-free strawberry gummy bear for active kids ages 3–6+. Four thoughtfully selected ingredients — calcium, vitamin D3, zinc, and L-lysine — chosen to support healthy growth and strong bones during childhood's biggest building years.
Thoughtfully selected ingredients
Per 3 gummies. Children ages 3–6+ take 3 gummies daily with food, or as directed by a health-care professional.
Calcium
Supports bone & teeth development. Calcium lactate is a gentle, well-tolerated form for young kids.
Vitamin D3
Helps calcium & nutrient absorption. Equivalent to 900 IU of cholecalciferol.
Zinc
Supports immune health & growth. Essential mineral involved in hundreds of enzymes.
L-Lysine
Supports healthy appetite. Essential amino acid studied for enhancing calcium absorption.
How it all works together
Absorb the calcium
Vitamin D3 is converted to its active form and signals the gut to produce calcium-binding proteins — helping the calcium in food and supplements actually get into the body.
Boost calcium uptake
L-lysine has been studied in humans for its ability to increase intestinal calcium absorption and reduce urinary calcium loss — so more of what kids consume actually reaches growing bones.
Fuel healthy growth
Zinc is a required cofactor in over 300 enzymes, including those involved in cell division, protein synthesis, and the activity of osteoblasts — the cells that build new bone.
The essential takeaways
- Most of a person's peak bone mass is built before adulthood — making childhood an important window for bone nutrition.
- Calcium and vitamin D3 are the two foundational nutrients for building bone, and they work as a pair: vitamin D helps the body actually absorb the calcium it gets.
- Zinc has been shown across multiple meta-analyses to support healthy growth in children, with particularly consistent effects after age 2.
- L-lysine has been studied in humans for its role in increasing the intestinal absorption of dietary calcium.
- All referenced studies examine individual active ingredients, not Amp Up branded products. Parents should consult a pediatrician before giving any supplement to a child.
The research
Calcium — bone mineral content in healthy children
Winzenberg et al. pooled 19 placebo-controlled RCTs of calcium supplementation in healthy children, examining bone mineral content (BMC) across the skeleton.
- Produced a small but statistically significant increase in total body bone mineral content and in upper-limb bone mineral density in supplemented children.1
- Confirms calcium's foundational role as the mineral most responsible for skeletal mass during growth.1
- Over 90% of peak bone mass is attained by the late teens, making early-life intake particularly relevant for lifelong bone health.1
Total body bone mineral content — Winzenberg et al., 2006
Pooled standardized mean difference across 19 RCTs
Vitamin D3 — bone density support in children
An individual-participant-data (IPD) meta-analysis of vitamin D supplementation RCTs in children aged 1–19 years, examining bone density outcomes.
- Significant bone density gains observed in children with inadequate baseline vitamin D levels who received supplementation.2
- Supports targeted supplementation for kids whose dietary intake or sun exposure is insufficient — a common scenario in modern indoor-heavy childhoods.2
Zinc — linear growth in healthy children over age 2
A 2023 meta-analysis pooled 8 RCTs examining zinc supplementation and growth parameters in healthy children over 2 years of age — the relevant age range for Kids Bone Support.
- Significantly increased height in supplemented children vs. placebo.3
- Significantly increased weight and improved weight-for-age z-score.3
- Effects were strongest in children age 2+, matching the recommended age window for this product.3
Zinc — linear growth across 78 clinical trials
Liu et al. conducted a large systematic review of 78 randomized controlled trials covering over 34,000 participants, examining zinc supplementation on child growth outcomes.
- Zinc supplementation after birth significantly increased height (WMD 0.23 cm) and weight (WMD 0.14 kg).4
- Effects were particularly pronounced in children supplemented from age 2 or older.4
L-Lysine — intestinal calcium absorption in humans
Civitelli et al. conducted a landmark human study on L-lysine's effect on calcium metabolism — comparing L-lysine against L-valine and L-tryptophan on calcium absorption.
- L-lysine significantly increased intestinal calcium absorption, while the other amino acids tested did not produce the same effect.5
- L-lysine also reduced urinary calcium excretion, meaning more absorbed calcium is retained for use in bones.5
- Combined effects may contribute to a more positive calcium balance — one of the key reasons L-lysine pairs so well with calcium and vitamin D.5
Calcium Lysinate — bioavailability comparison
A randomized open-label study directly comparing calcium-lysine combinations against calcium carbonate and calcium citrate malate on absorption and bone mineral density outcomes.
- Demonstrated substantially higher calcium bioavailability when calcium was paired with lysine — supporting the rationale for combining the two in a children's formula.6
- Significant improvement in bone mineral density T-scores in the calcium-lysine group.6
1 Meta-analysis of 19 RCTs, n=2,859. Winzenberg T et al., BMJ, 2006. PMID: 16980314.
2 IPD meta-analysis. Systematic review & IPD meta-analysis of vitamin D RCTs in children 1–19 y. Am J Clin Nutr, 2023.
3 Meta-analysis of 8 RCTs, n=1,586. Khademi M et al., BMC Pediatrics, 2023. PMC: PMC10464267.
4 Meta-analysis of 78 RCTs, n=34,352. Liu E et al., Nutrients, 2018. PMC: PMC5872795.
5 Civitelli R et al., J Bone Miner Res, 1992. PMID: 1486246.
6 Shankar K et al., J Orthop Case Reports, 2018.
* These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
** All referenced studies examine individual active ingredients, not Amp Up branded products. Consult your pediatrician before giving any supplement to a child.
